Mitchell, who has plied his trade in France with Toulon since 2013, revealed on Twitter on Monday that he was calling time on his career after winning 71 caps for Australia between 2005 and 2016.
The 33-year-old has desperately struggled with injury since returning to the Wallabies squad for the last World Cup in England back in 2015.
He generally peaked for World Cups and ended up with 14 tries, just one short of the record shared by Jonah Lomu and South Africa's Bryan Habana.
