Police said they would work with the NSW Crime Commission and they have the full support of the NRL.
Dozens of players, officials and members of the public are expected to be interviewed.
Earlier this year, the Organised Crime Squad confirmed it was investigating allegations of match-fixing in two NRL games from last year.
Those games were a round 16 game between the Manly Sea Eagles and the South Sydney Rabbitohs, and a round 24 match between Manly and the Parramatta Eels.