Adriaan Strauss, who will win his 50th cap, is the starting hooker, while Duane Vermeulen will make his first Test appearance of the year in the No 8 jersey as coach Heyneke Meyer reacted swiftly to the shock of defeat against Japan.
Willie le Roux, JP Pietersen and Damian De Allende return in the backline – with skipper Jean de Villiers shifting to outside centre – while there are new halfbacks in Handré Pollard and Fourie du Preez.