The venerable actress had some harsh words for the material girl during her Tuesday night appearance on "Watch What Happens Live."
She cut loose after a caller inquired as to whether she and Madonna had ever discussed their "two iconic performances as Evita."
LuPone won a Tony Award in 1980 for her starring role the Broadway musical "Evita," based on the life of Argentina's former first lady, Eva PerĂ³n.
Madonna won a Golden Globe for her starring role the 1996 film adaption of the musical, but LuPone is not impressed.