In topping the chart she has ended the reign of Ed Sheeran, who has been the UK's most-played artist every year since 2017.
Two of her singles, Physical and Don't Start Now, were among the 10 most popular songs on the UK airwaves.
The most-played track overall was The Weeknd's Blinding Lights.
The figures were compiled by music licensing company PPL, which monitors the music played on TV and radio and in pubs and clubs.
It said Sheeran was the year's second most-played artist, followed by Ariana Grande and Sam Smith.