The bodies of the dead pair were found inside a car in the driveway of a property caught in the blaze.
Siskiyou County Sheriff Jeremiah LaRue told ABC News the two seemed to be trying to escape the area.
The McKinney Fire has burned more than 52,000 acres, making it California's largest this year.
The identities of the two dead people are not being released until their families have been notified.