The uncapped halfback was missing from yesterday’s training session in Twickenham and will now have to wait to earn his first England cap.
An England Rugby statement reads: “Harry Randall has withdrawn from the England squad for the Guinness Six Nations with an ankle injury.
“Alex Mitchell has been called-up to Eddie Jones’ 28-player squad. England are preparing for their next match, against Wales, at their training base – The Lensbury in Teddington.