The gig in August will be the only chance fans get to see the Fresh Prince of Bel Air and his hip-hop partner perform in the UK this year.
A spokesperson for the Livewire Festival said: "We can't wait to bring them to Blackpool! It's the best location in the UK for entertainment."
Sinitta, The Jacksons and Jason Donovan are also performing.
DJ Jazzy Jeff and Will Smith, a.k.a the Fresh Prince of Bel Air, met in the 1980s and won a Grammy for their single Parents Just Don't Understand.
