The cash value option of the jackpot is $780.5m. The winner can choose to take the cash outright or be paid the full jackpot in instalments over 29 years.
The odds of winning the jackpot in Friday's draw were rather slim - one in 300 million.
The largest Mega Millions prize to date was $1.537bn in 2018.
It was won by a single ticket sold in South Carolina. The 2016 Powerball prize, however, remains the largest jackpot in US history - $1.586bn - shared by three winners.
The winning numbers for Friday night's Mega Millions draw were 13, 36, 45, 57 and 67 - with a Mega Ball of 14.
The final prize was bigger than original estimate, due to high sales.
The Mega Millions website shows there was one winner, and company officials later confirmed that the ticket was sold in Illinois. No winner has yet come forward.
The last time someone won the Mega Millions jackpot was 15 April in Tennessee. Since then, Americans have rushed to buy tickets as the prize swelled.
Mega Millions tickets are sold in 45 US states, Washington DC and the US Virgin Islands.