Sky gazers around the world are congregating near landmarks, on beaches and atop tall buildings to take a look.
The 'supermoon' reached its brightest in Asia on Monday evening.
The Moon was closest - only 221,524 miles (356,509km) away - at 11:21 GMT.
The moon orbits the Earth in an ellipse, not a circle, so it is sometimes closer to the Earth than it is at other times.
When the perigee - the closest approach - and the full moon coincide, it is known as a supermoon.
This supermoon was best seen in North America early on Monday, before dawn. The UK's best chance to see it will be on Monday evening.
Supermoons appear about 14% larger and 30% brighter when compared with the furthest point the Moon gets to within its orbit.
The moon will not be this close again until 25 November 2034 - when it will be even closer, within 221,485 miles.
Those hoping to get a good picture are advised to take a photo of the moon with a reference point, like a landmark, in frame.
If you're using a digital SLR - use a daylight white balance setting to capture moonlight, Nasa photographer Bill Ingalls advises.