The magazine featured four different covers with journalists who have been targeted for their work this year.
They include Jamal Khashoggi who was killed in the Saudi embassy in Turkey.
Staff from Capital Gazette, the US newspaper where five people were killed, are featured, along with Maria Ressa of the Philippines and the wives of Myanmar's Wa Lone and Kyaw Soe Oo.
Time said they were chosen "for taking great risks in pursuit of greater truths, for the imperfect but essential quest for facts, for speaking up and for speaking out".
