Two tries in each half, from Jonny May, Courtney Lawes, George Ford and Owen Farrell, were a fair reflection of England's dominance against a team they had not beaten since 2006.
While England can celebrate ending a run of 11 defeats and a draw in the fixture, South Africa know they have a lot of rebuilding to do after slumping to their fifth defeat in six matches and never looking remotely like doing anything else.
The only time they were in the game was in the opening 20 minutes as Pat Lambie's boot cashed in on England's indiscipline.