After retaining his WBA world welterweight title on Saturday, the Filipino challenged five-weight world champion Mayweather, 41, to a rematch.
The retired Mayweather was ringside in Las Vegas watching Pacquiao beat American Adrien Broner with a unanimous points win.
In the post-fight press conference Pacquiao was repeatedly asked about the prospect of fighting the American again.
"My message is I'm still active, and if [Mayweather] goes back to the ring and wants to challenge me, I'm a champion. Get back to the ring and we will fight again if he wants," Pacquiao said.
"If he wants to come out of retirement, then announce it and challenge me. I'm a champion and I don't pick any opponent. I'm just waiting to see who will challenge me, who will challenge for my belt."