The ceremony is traditionally seen as an indicator of which films will do well at the Oscars.
La La Land leads the field with seven nominations, followed by Moonlight (six) and Manchester By The Sea (five).
The Globes also cover TV - and this year sees British actors including Claire Foy, Tom Hiddleston and Thandie Newton hotly tipped for trophies.
The awards will be handed out in Los Angeles from 17:00 PST Sunday/01:00 GMT Monday at a ceremony hosted by Jimmy Fallon.
La La Land, which stars Ryan Gosling and Emma Stone, tells the story of a jazz pianist and an aspiring actress who are chasing dreams of stardom in Los Angeles.
Its nominations include best comedy or musical film, where it faces competition from Florence Foster Jenkins, Sing Street, 20th Century Women and Deadpool.
The musical is also in the running for best screenplay and best director, while Stone and Gosling have both received acting nods.
Its director Damien Chazelle told the BBC: "I grew up loving those old Hollywood musicals, and what I wanted to do was to take that form of film-making we think of as old fashioned and see if it could be updated and revived for today."
The best drama film category is likely to be more hotly contested, with Moonlight and Manchester By The Sea the frontrunners.
Moonlight tells the story of a young gay black man growing up in an impoverished neighbourhood in Miami.
British actress Naomie Harris is nominated for best supporting actress for her role in the film - a part she initially wanted to turn down.
"I didn't want to do it because I didn't want to play a crack addict - I wanted to portray positive images of women in general and black women in particular," she told the BBC last month.
"So I stupidly was about to say no, but then the director said, 'I'm basically asking you to play my mum', and I thought, I've never had anyone ask me to do that before, and it's his story."
Moonlight is also nominated for best director, best screenplay, and best supporting actor for Mahershala Ali.
Meanwhile, Manchester By The Sea, which stars Casey Affleck, Michelle Williams and Lucas Hedges, has already been named best film of the year by the National Board of Review.
Florence Foster Jenkins, which stars Meryl Streep and Hugh Grant, and Lion, with Nicole Kidman and Dev Patel, have four nominations apiece.
In the television categories, The Crown's British star Claire Foy is nominated for best leading drama actress for her portrayal of Queen Elizabeth II in her younger years.
The Crown has been made by streaming service Netflix with a reported £100m budget.
Thandie Newton, who appears in HBO drama Westworld, is nominated for best supporting TV actress, as is Olivia Colman for The Night Manager.
Her nomination is one of four for the BBC spy drama. Tom Hiddleston is up for best TV drama actor and Hugh Laurie is up for best TV supporting actor, while the show itself is nominated for best mini-series.
Other British contenders include Riz Ahmed, who is up against Hiddleston in the TV drama actor category for The Night Of, Charlotte Rampling for London Spy, and Matthew Rhys for The Americans.
The People vs OJ Simpson leads the television nominations, with five in total.